Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.

Aminoglycoside antibiotics induce an early and characteristic lysosomal phospholipidosis in cultured fibroblasts and in kidney tubular cells. We have recently demonstrated an inhibition of lysosomal phospholipases A1 and A2 by gentamicin and amikacin in vitro. In vivo, gentamicin decreases the activ...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Carlier, M B, Laurent, G, Claes, P J, Vanderhaeghe, H J, Tulkens, P M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC184667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6847172/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.3.440
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