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A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of γ chains by factor XIII(a)

The E domain of fibrinogen represents the central region of the protein that, after the removal of fibrinopeptides from the N-termini of its α chains by thrombin, orders the noncovalent assembly of fibrin units into a half-staggered array. This structural organization is accomplished purely through...

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Bibliografiska uppgifter
Huvudupphovsmän: Lorand, Laszlo, Parameswaran, Kumarapuram N., Murthy, S. N. Prasanna
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1998
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC18455/
https://ncbi.nlm.nih.gov/pubmed/9435227
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