A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of γ chains by factor XIII(a)
The E domain of fibrinogen represents the central region of the protein that, after the removal of fibrinopeptides from the N-termini of its α chains by thrombin, orders the noncovalent assembly of fibrin units into a half-staggered array. This structural organization is accomplished purely through...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.2.537 |
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