Genetic Variation at the Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Locus Modulates Wnt Signaling and the Relationship of Physical Activity with Bone Mineral Density in Men

Polymorphisms in the LRP5 gene have been associated with bone mineral density (BMD) in men and/or women. However, the functional basis for this association remains obscure. We hypothesized that LRP5 alleles could modulate Wnt signaling and the relationship between physical activity and BMD. This gen...

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Hlavní autoři: Kiel, Douglas P., Ferrari, Serge L., Cupples, L. Adrienne, Karasik, David, Manen, Danielle, Imamovic, Alma, Herbert, Alan G., Dupuis, Josée
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1845172/
https://ncbi.nlm.nih.gov/pubmed/17137849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2006.09.029
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