Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to be a key player in cancer progression. Here, using fluorescent reporters, we shown in cells that, contrary to in vitro analyses, 3-phosphoinositide–dependent...

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Détails bibliographiques
Auteurs principaux: Calleja, Véronique, Alcor, Damien, Laguerre, Michel, Park, Jongsun, Vojnovic, Borivoj, Hemmings, Brian A, Downward, Julian, Parker, Peter J, Larijani, Banafshé
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1845162/
https://ncbi.nlm.nih.gov/pubmed/17407381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050095
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