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Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells

Most current anticancer therapies act by inducing tumor cell stasis followed by apoptosis. HIV-1 Vpr effectively induces apoptosis of T cells after arrest of cells at a G(2)/M checkpoint. Here, we investigated whether this property of Vpr could be exploited for use as a potential anticancer agent. A...

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Bibliografiske detaljer
Main Authors: Stewart, Sheila A., Poon, Betty, Jowett, Jeremy B. M., Xie, Yiming, Chen, Irvin S. Y.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18408/
https://ncbi.nlm.nih.gov/pubmed/10518572
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