Impairment of Human Immunodeficiency Virus Type 1 (HIV-1) Entry into Jurkat T Cells by Constitutive Expression of the HIV-1 Vpr Protein: Role of CD4 Down-Modulation

Jurkat T-cell clones, stably expressing the human immunodeficiency virus type 1 (HIV-1) Vpr protein, exhibited an impaired susceptibility to HIV-1 infection. A marked down-modulation of surface CD4 receptors was detected in Vpr-expressing clones with respect to control cells. Likewise, a reduced CD4...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Conti, Lucia, Varano, Barbara, Gauzzi, M. Cristina, Matarrese, Paola, Federico, Maurizio, Malorni, Walter, Belardelli, Filippo, Gessani, Sandra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024150/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.21.10207-10211.2000
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