Impairment of Human Immunodeficiency Virus Type 1 (HIV-1) Entry into Jurkat T Cells by Constitutive Expression of the HIV-1 Vpr Protein: Role of CD4 Down-Modulation

Jurkat T-cell clones, stably expressing the human immunodeficiency virus type 1 (HIV-1) Vpr protein, exhibited an impaired susceptibility to HIV-1 infection. A marked down-modulation of surface CD4 receptors was detected in Vpr-expressing clones with respect to control cells. Likewise, a reduced CD4...

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Détails bibliographiques
Auteurs principaux: Conti, Lucia, Varano, Barbara, Gauzzi, M. Cristina, Matarrese, Paola, Federico, Maurizio, Malorni, Walter, Belardelli, Filippo, Gessani, Sandra
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC102060/
https://ncbi.nlm.nih.gov/pubmed/11024150
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