Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells

Most current anticancer therapies act by inducing tumor cell stasis followed by apoptosis. HIV-1 Vpr effectively induces apoptosis of T cells after arrest of cells at a G(2)/M checkpoint. Here, we investigated whether this property of Vpr could be exploited for use as a potential anticancer agent. A...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Stewart, Sheila A., Poon, Betty, Jowett, Jeremy B. M., Xie, Yiming, Chen, Irvin S. Y.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18408/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10518572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.21.12039
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