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The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity
Studies of protein kinases have identified a “gatekeeper” residue, which confers selectivity for binding nucleotides and small-molecule inhibitors. We report that, in the MAP kinase ERK2, mutations at the gatekeeper residue unexpectedly lead to autoactivation due to enhanced autophosphorylation of r...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
2006
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838713/ https://ncbi.nlm.nih.gov/pubmed/17114285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608849103 |
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