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U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing
To ligate exons in pre-messenger RNA (pre-mRNA) splicing, the spliceosome must reposition the substrate after cleaving the 5′ splice site. Because spliceosomal small nuclear RNAs (snRNAs) bind the substrate, snRNA structures may rearrange to reposition the substrate. However, such rearrangements hav...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838533/ https://ncbi.nlm.nih.gov/pubmed/17403782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1536107 |
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