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PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
The coactivator PGC-1α mediates key responses of skeletal muscle to motor nerve activity. We show here that neuregulin-stimulated phosphorylation of PGC-1α and GA-binding protein (GABP) allows recruitment of PGC-1α to the GABP complex and enhances transcription of a broad neuromuscular junction gene...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838529/ https://ncbi.nlm.nih.gov/pubmed/17403779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1525107 |
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