Genome plasticity of BCG and impact on vaccine efficacy

To understand the evolution, attenuation, and variable protective efficacy of bacillus Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected to comparative genome and transcriptome analysis. The 4,374,522-bp genome contains 3,954 protein-coding genes, 58 of which...

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Detalhes bibliográficos
Main Authors: Brosch, Roland, Gordon, Stephen V., Garnier, Thierry, Eiglmeier, Karin, Frigui, Wafa, Valenti, Philippe, Dos Santos, Sandrine, Duthoy, Stéphanie, Lacroix, Céline, Garcia-Pelayo, Carmen, Inwald, Jacqueline K., Golby, Paul, Garcia, Javier Nuñez, Hewinson, R. Glyn, Behr, Marcel A., Quail, Michael A., Churcher, Carol, Barrell, Bart G., Parkhill, Julian, Cole, Stewart T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838518/
https://ncbi.nlm.nih.gov/pubmed/17372194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700869104
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