A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across Mycobacterium bovis Strains and M. bovis BCG Vaccine Strains Refines the Genealogy and Defines a Minimal Set of SNPs That Separate Virulent M. bovis Strains and M. bovis BCG Strains

To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to identify single nucleotide polymorphisms (SNPs) that differed between sequenced strains of Mycobacterium bovis and M. bovis BCG. SNPs were assayed in M....

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Bibliographische Detailangaben
Hauptverfasser: Garcia Pelayo, M. Carmen, Uplekar, Swapna, Keniry, Andrew, Mendoza Lopez, Pablo, Garnier, Thierry, Nunez Garcia, Javier, Boschiroli, Laura, Zhou, Xiangmei, Parkhill, Julian, Smith, Noel, Hewinson, R. Glyn, Cole, Stewart T., Gordon, Stephen V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Molecular Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681724/
https://ncbi.nlm.nih.gov/pubmed/19289514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01099-08
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