A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across Mycobacterium bovis Strains and M. bovis BCG Vaccine Strains Refines the Genealogy and Defines a Minimal Set of SNPs That Separate Virulent M. bovis Strains and M. bovis BCG Strains

To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to identify single nucleotide polymorphisms (SNPs) that differed between sequenced strains of Mycobacterium bovis and M. bovis BCG. SNPs were assayed in M....

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Bibliografische gegevens
Hoofdauteurs: Garcia Pelayo, M. Carmen, Uplekar, Swapna, Keniry, Andrew, Mendoza Lopez, Pablo, Garnier, Thierry, Nunez Garcia, Javier, Boschiroli, Laura, Zhou, Xiangmei, Parkhill, Julian, Smith, Noel, Hewinson, R. Glyn, Cole, Stewart T., Gordon, Stephen V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
Onderwerpen:
Molecular Genomics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681724/
https://ncbi.nlm.nih.gov/pubmed/19289514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01099-08
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