Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells

The intracellular activation of trypsinogen, which is both pH- and calcium-dependent, is an important early step in the development of acute pancreatitis. The cellular compartment in which trypsinogen activation occurs currently is unknown. We therefore investigated the site of intracellular trypsin...

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Main Authors: Sherwood, Mark W., Prior, Ian A., Voronina, Svetlana G., Barrow, Stephanie L., Woodsmith, Jonathan D., Gerasimenko, Oleg V., Petersen, Ole H., Tepikin, Alexei V.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838486/
https://ncbi.nlm.nih.gov/pubmed/17363470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700951104
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