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Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-I

Thienamycin (THM), the N-formimidoyl thienamycin derivative MK0787, and related carbapenem antibiotics were metabolized extensively in mice, rats, rabbits, dogs, rhesus monkeys, and chimpanzees. Urinary recovery of THM ranged from a low of 5% in dogs to 58% in rhesus monkeys. Renal clearance rates i...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Principais autores: Kropp, Helmut, Sundelof, Jon G., Hajdu, Richard, Kahan, Frederick M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1982
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC183675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7125632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.22.1.62
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