Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL

We have synthesized a new benzomorphan derivative, 2R-[2α,3(S*),6α]-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[2-(phenylmethoxy)propyl]-2,6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL), which displaced [(3)H]batrachotoxinin A-20α-benzoate from neurotoxin receptor site 2 of the Na(+) channe...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Carter, Adrian J., Grauert, Matthias, Pschorn, Uwe, Bechtel, Wolf Dietrich, Bartmann-Lindholm, Christina, Qu, Yusheng, Scheuer, Todd, Catterall, William A., Weiser, Thomas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10781102/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040577097
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