Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin

Abstract The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels. By using cryogenic electron microscopy, we identify two homologous, but nonidentical receptor sites that simultaneous...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2024-03-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-024-45958-w
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!