2,2,2-Trifluoroethanol Changes the Transition Kinetics and Subunit Interactions in the Small Bacterial Mechanosensitive Channel MscS

2,2,2-Trifluoroethanol (TFE), a low-dielectric solvent, has recently been used as a promising tool to probe the strength of intersubunit interactions in membrane proteins. An analysis of inner membrane proteins of Escherichia coli has identified several SDS-resistant protein complexes that separate...

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Autores principales: Akitake, Bradley, Spelbrink, Robin E. J., Anishkin, Andriy, Killian, J. Antoinette, de Kruijff, Ben, Sukharev, Sergei
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2007
Materias:
Channels, Receptors, and Electrical Signaling
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831691/
https://ncbi.nlm.nih.gov/pubmed/17277184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098715
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