The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

BACKGROUND: Mutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. PINK1 is expressed abundantly in mitochondria rich tissues, such as skeletal muscle, where it plays a critical role determining mitochondrial structural integrity in Drosophila...

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Main Authors: Scheele, Camilla, Petrovic, Natasa, Faghihi, Mohammad A, Lassmann, Timo, Fredriksson, Katarina, Rooyackers, Olav, Wahlestedt, Claes, Good, Liam, Timmons, James A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831481/
https://ncbi.nlm.nih.gov/pubmed/17362513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-8-74
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