Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans

The genome of Caenorhabditis elegans possesses two genes, dpy-18 and phy-2, that encode α subunits of the enzyme prolyl 4-hydroxylase. We have generated deletions within each gene to eliminate prolyl 4-hydroxylase activity from the animal. The dpy-18 mutant has an aberrant body morphology, consisten...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Friedman, Lisa, Higgin, Joshua J., Moulder, Gary, Barstead, Robert, Raines, Ronald T., Kimble, Judith
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2000
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10781079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.9.4736
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