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CSN controls NF-κB by deubiquitinylation of IκBα
The COP9 signalosome (CSN) is a conserved protein complex that regulates assembly and activity of cullin-RING ubiquitin ligases (CRLs). Ubiquitin-dependent degradation of the NF-κB inhibitor IκBα preceeds nuclear translocation of NF-κB. For the first time, we show here an inducible interaction of th...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829370/ https://ncbi.nlm.nih.gov/pubmed/17318178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601600 |
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