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Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15and PKA by a modified leucine zipper motif

In hippocampal pyramidal cells, dopamine acts at D1 receptors to reduce peak Na(+) currents by activation of phosphorylation by PKA anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which AKAP15 anchors PKA to neuronal Na(+) channels is not known. By using a strategy of...

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Main Authors: Few, W. Preston, Scheuer, Todd, Catterall, William A.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829284/
https://ncbi.nlm.nih.gov/pubmed/17360357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611619104
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