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Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15and PKA by a modified leucine zipper motif
In hippocampal pyramidal cells, dopamine acts at D1 receptors to reduce peak Na(+) currents by activation of phosphorylation by PKA anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which AKAP15 anchors PKA to neuronal Na(+) channels is not known. By using a strategy of...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829284/ https://ncbi.nlm.nih.gov/pubmed/17360357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611619104 |
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