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A Leucine Zipper Motif in the Cytoplasmic Domain of gp41 Is Required for HIV-1 Replication and Pathogenesis in Vivo
A leucine zipper motif is conserved in the cytoplasmic domain of glycoprotein gp41 (gp41c) of all HIV-1 subtypes, but is not present in HIV-2 or SIV. The second leucine residue of the leucine zipper was mutated (L95R) to determine the role of this motif in HIV-1 replication and pathogenesis. The L95...
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| Publicado no: | Virology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4435951/ https://ncbi.nlm.nih.gov/pubmed/11689043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/viro.2001.1112 |
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