Sequencing of the pncA Gene in Members of the Mycobacterium tuberculosis Complex Has Important Diagnostic Applications: Identification of a Species-Specific pncA Mutation in “Mycobacterium canettii” and the Reliable and Rapid Predictor of Pyrazinamide Resistance

Testing for susceptibility to pyrazinamide (PZA) and analysis of the pncA gene sequences of 423 Mycobacterium tuberculosis complex isolates have revealed a unique silent nucleotide substitution that enables the rapid identification of “M. canettii” (proposed name). Moreover, the lack of a defined mu...

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Bibliografiske detaljer
Main Authors: Somoskovi, Akos, Dormandy, Jillian, Parsons, Linda M., Kaswa, Michel, Goh, Khye Seng, Rastogi, Nalin, Salfinger, Max
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Mycobacteriology and Aerobic Actinomycetes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829052/
https://ncbi.nlm.nih.gov/pubmed/17135430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01454-06
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