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Perturbed ATPase activity and not “close confinement” of substrate in the cis cavity affects rates of folding by tail-multiplied GroEL

Folding of substrate proteins inside the sequestered and hydrophilic GroEL-GroES cis cavity favors production of the native state. Recent studies of GroEL molecules containing volume-occupying multiplications of the flexible C-terminal tail segments have been interpreted to indicate that close confi...

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Detalhes bibliográficos
Main Authors: Farr, George W., Fenton, Wayne A., Horwich, Arthur L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828711/
https://ncbi.nlm.nih.gov/pubmed/17372195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700820104
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