PKA modulates GSK-3β- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

Phosphorylation of tau protein is regulated by several kinases, especially glycogen synthase kinase 3β (GSK-3β), cyclin-dependent protein kinase 5 (cdk5) and cAMP-dependent protein kinase (PKA). Phosphorylation of tau by PKA primes it for phosphorylation by GSK-3β, but the site-specific modulation o...

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Bibliografiske detaljer
Main Authors: Liu, Fei, Liang, Zhihou, Shi, Jianhua, Yin, Dongmei, El-Akkad, Ezzat, Grundke-Iqbal, Inge, Iqbal, Khalid, Gong, Cheng-Xin
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828604/
https://ncbi.nlm.nih.gov/pubmed/17078951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.10.033
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