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Mutants of Type II Heat-Labile Enterotoxin LT-IIa with Altered Ganglioside-Binding Activities and Diminished Toxicity Are Potent Mucosal Adjuvants

The structure and function LT-IIa, a type II heat-labile enterotoxin of Escherichia coli, are closely related to the structures and functions of cholera toxin and LT-I, the type I heat-labile enterotoxins of Vibrio cholerae and enterotoxigenic Escherichia coli, respectively. While LT-IIa is a potent...

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Autors principals: Nawar, Hesham F., Arce, Sergio, Russell, Michael W., Connell, Terry D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828530/
https://ncbi.nlm.nih.gov/pubmed/17118982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01009-06
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