Secretion of Functional Monocyte Chemotactic Protein 3 by Recombinant Mycobacterium bovis BCG Attenuates Vaccine Virulence and Maintains Protective Efficacy against M. tuberculosis Infection

A strain of Mycobacterium bovis BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG(MCP-3)) was developed. Mice vaccinated with BCG(MCP-3) displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated w...

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Autores principales: Ryan, Anthony A., Spratt, Joanne M., Britton, Warwick J., Triccas, James A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828426/
https://ncbi.nlm.nih.gov/pubmed/17074853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00897-06
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