A Nedd8 conjugation pathway is essential for proteolytic targeting of p27(Kip1) by ubiquitination

Temporal control of p27(Kip1) (p27) degradation imposes periodicity in its activity during cell cycle progression and its accumulation during cell cycle exit. Degradation of p27 is initiated by phosphorylation of p27 at Thr-187, which marks the protein for ubiquitination by SCF(Skp2) and subsequent...

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Main Authors: Podust, Vladimir N., Brownell, James E., Gladysheva, Tatiana B., Luo, Rong-Shu, Wang, Chunhua, Coggins, Michael B., Pierce, Jacqueline W., Lightcap, Eric S., Chau, Vincent
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC18275/
https://ncbi.nlm.nih.gov/pubmed/10781063
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