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Aerosolized Cidofovir Is Retained in the Respiratory Tract and Protects Mice against Intranasal Cowpox Virus Challenge

We employed a murine model to test the concept of using an aerosolized, long-acting antiviral drug to protect humans against smallpox. We previously showed that a low dose of aerosolized cidofovir (HPMPC [Vistide]) was highly protective against subsequent aerosolized cowpox virus challenge and was m...

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Autori principali: Roy, Chad J., Baker, Robert, Washburn, Kenneth, Bray, Mike
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC182607/
https://ncbi.nlm.nih.gov/pubmed/12936997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.9.2933-2937.2003
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