Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine

Mutations resulting in replacement of one obligate Gly residue within the repeating (Gly-Xaa-Yaa)(n) triplet pattern of the collagen type I triple helix are the major cause of osteogenesis imperfecta (OI). Phenotypes of OI involve fragile bones and range from mild to perinatal lethal. In this study,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Beck, Konrad, Chan, Virginia C., Shenoy, Nigel, Kirkpatrick, Alan, Ramshaw, John A. M., Brodsky, Barbara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10725403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.070050097
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