Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine

Mutations resulting in replacement of one obligate Gly residue within the repeating (Gly-Xaa-Yaa)(n) triplet pattern of the collagen type I triple helix are the major cause of osteogenesis imperfecta (OI). Phenotypes of OI involve fragile bones and range from mild to perinatal lethal. In this study,...

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Main Authors: Beck, Konrad, Chan, Virginia C., Shenoy, Nigel, Kirkpatrick, Alan, Ramshaw, John A. M., Brodsky, Barbara
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2000
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC18226/
https://ncbi.nlm.nih.gov/pubmed/10725403
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