Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine
Mutations resulting in replacement of one obligate Gly residue within the repeating (Gly-Xaa-Yaa)(n) triplet pattern of the collagen type I triple helix are the major cause of osteogenesis imperfecta (OI). Phenotypes of OI involve fragile bones and range from mild to perinatal lethal. In this study,...
Kaydedildi:
| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10725403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.070050097 |
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