Sequence-specific modification of genomic DNA by small DNA fragments

Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic editing, known as small-fragment homologous replacement (SFHR), has yet to be characterized in terms of its underlying mechanisms. Genotypic...

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מידע ביבליוגרפי
Main Authors: Gruenert, Dieter C., Bruscia, Emanuela, Novelli, Giuseppe, Colosimo, Alessia, Dallapiccola, Bruno, Sangiuolo, Federica, Goncz, Kaarin K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2003
נושאים:
Perspective Series
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC182219/
https://ncbi.nlm.nih.gov/pubmed/12952908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319773
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