Sequence-specific modification of genomic DNA by small DNA fragments

Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic editing, known as small-fragment homologous replacement (SFHR), has yet to be characterized in terms of its underlying mechanisms. Genotypic...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Gruenert, Dieter C., Bruscia, Emanuela, Novelli, Giuseppe, Colosimo, Alessia, Dallapiccola, Bruno, Sangiuolo, Federica, Goncz, Kaarin K.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2003
Assuntos:	Perspective Series
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12952908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19773
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