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CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4(+) T cells
T cell receptor engagement with CD28 costimulation is generally required for naive T cell activation, whereas reactivation of memory cells is less dependent on CD28 costimulation. We studied this process in chronic beryllium disease, in which the frequency of antigen-specific CD4(+) T cells in the l...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC182206/ https://ncbi.nlm.nih.gov/pubmed/12952926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318317 |
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