CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4(+) T cells

T cell receptor engagement with CD28 costimulation is generally required for naive T cell activation, whereas reactivation of memory cells is less dependent on CD28 costimulation. We studied this process in chronic beryllium disease, in which the frequency of antigen-specific CD4(+) T cells in the l...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Fontenot, Andrew P., Gharavi, Laia, Bennett, Sean R., Canavera, Scott J., Newman, Lee S., Kotzin, Brian L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2003
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12952926/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18317
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