CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4(+) T cells

T cell receptor engagement with CD28 costimulation is generally required for naive T cell activation, whereas reactivation of memory cells is less dependent on CD28 costimulation. We studied this process in chronic beryllium disease, in which the frequency of antigen-specific CD4(+) T cells in the l...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Fontenot, Andrew P., Gharavi, Laia, Bennett, Sean R., Canavera, Scott J., Newman, Lee S., Kotzin, Brian L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2003
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12952926/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18317
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