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CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4(+) T cells

T cell receptor engagement with CD28 costimulation is generally required for naive T cell activation, whereas reactivation of memory cells is less dependent on CD28 costimulation. We studied this process in chronic beryllium disease, in which the frequency of antigen-specific CD4(+) T cells in the l...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fontenot, Andrew P., Gharavi, Laia, Bennett, Sean R., Canavera, Scott J., Newman, Lee S., Kotzin, Brian L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC182206/
https://ncbi.nlm.nih.gov/pubmed/12952926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318317
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