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Agonist Versus Antagonist Action of ATP at the P2Y(4) Receptor Is Determined by the Second Extracellular Loop
UTP is a potent full agonist at both the human P2Y(4) (hP2Y(4)) and rat P2Y(4) (rP2Y(4)) receptor. In contrast, ATP is a potent full agonist at the rP2Y(4) receptor but is a similarly potent competitive antagonist at the hP2Y(4) receptor. To delineate the structural determinants of agonism versus an...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1821344/ https://ncbi.nlm.nih.gov/pubmed/14670966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M301734200 |
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