Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance

PPARγ is essential for adipogenesis and metabolic homeostasis. We describe mutations in the DNA and ligand binding domains of human PPARγ in lipodystrophic, severe insulin resistance. These receptor mutants lack DNA binding and transcriptional activity but can translocate to the nucleus, interact wi...

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Autors principals: Agostini, Maura, Schoenmakers, Erik, Mitchell, Catherine, Szatmari, Istvan, Savage, David, Smith, Aaron, Rajanayagam, Odelia, Semple, Robert, Luan, Jian'an, Bath, Louise, Zalin, Anthony, Labib, Mourad, Kumar, Sudhesh, Simpson, Helen, Blom, Dirk, Marais, David, Schwabe, John, Barroso, Inês, Trembath, Richard, Wareham, Nicholas, Nagy, Laszlo, Gurnell, Mark, O'Rahilly, Stephen, Chatterjee, Krishna
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2006
Matèries:
Short Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821092/
https://ncbi.nlm.nih.gov/pubmed/17011503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.09.003
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