Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance

PPARγ is essential for adipogenesis and metabolic homeostasis. We describe mutations in the DNA and ligand binding domains of human PPARγ in lipodystrophic, severe insulin resistance. These receptor mutants lack DNA binding and transcriptional activity but can translocate to the nucleus, interact wi...

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Main Authors: Agostini, Maura, Schoenmakers, Erik, Mitchell, Catherine, Szatmari, Istvan, Savage, David, Smith, Aaron, Rajanayagam, Odelia, Semple, Robert, Luan, Jian'an, Bath, Louise, Zalin, Anthony, Labib, Mourad, Kumar, Sudhesh, Simpson, Helen, Blom, Dirk, Marais, David, Schwabe, John, Barroso, Inês, Trembath, Richard, Wareham, Nicholas, Nagy, Laszlo, Gurnell, Mark, O'Rahilly, Stephen, Chatterjee, Krishna
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2006
Teme:
Short Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821092/
https://ncbi.nlm.nih.gov/pubmed/17011503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.09.003
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