Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance

PPARγ is essential for adipogenesis and metabolic homeostasis. We describe mutations in the DNA and ligand binding domains of human PPARγ in lipodystrophic, severe insulin resistance. These receptor mutants lack DNA binding and transcriptional activity but can translocate to the nucleus, interact wi...

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Detalhes bibliográficos
Main Authors: Agostini, Maura, Schoenmakers, Erik, Mitchell, Catherine, Szatmari, Istvan, Savage, David, Smith, Aaron, Rajanayagam, Odelia, Semple, Robert, Luan, Jian'an, Bath, Louise, Zalin, Anthony, Labib, Mourad, Kumar, Sudhesh, Simpson, Helen, Blom, Dirk, Marais, David, Schwabe, John, Barroso, Inês, Trembath, Richard, Wareham, Nicholas, Nagy, Laszlo, Gurnell, Mark, O'Rahilly, Stephen, Chatterjee, Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2006
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821092/
https://ncbi.nlm.nih.gov/pubmed/17011503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.09.003
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