Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance

PPARγ is essential for adipogenesis and metabolic homeostasis. We describe mutations in the DNA and ligand binding domains of human PPARγ in lipodystrophic, severe insulin resistance. These receptor mutants lack DNA binding and transcriptional activity but can translocate to the nucleus, interact wi...

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Main Authors: Agostini, Maura, Schoenmakers, Erik, Mitchell, Catherine, Szatmari, Istvan, Savage, David, Smith, Aaron, Rajanayagam, Odelia, Semple, Robert, Luan, Jian'an, Bath, Louise, Zalin, Anthony, Labib, Mourad, Kumar, Sudhesh, Simpson, Helen, Blom, Dirk, Marais, David, Schwabe, John, Barroso, Inês, Trembath, Richard, Wareham, Nicholas, Nagy, Laszlo, Gurnell, Mark, O'Rahilly, Stephen, Chatterjee, Krishna
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2006
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Short Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821092/
https://ncbi.nlm.nih.gov/pubmed/17011503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.09.003
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