15-Deoxyspergualin inhibits eukaryotic protein synthesis through eIF2α phosphorylation

DSG (15-deoxyspergualin), an immunosuppressant with tumoricidal properties, binds potently to the regulatory C-terminal ‘EEVD’ motif of Hsps (heat-shock proteins). In the present study we demonstrate that DSG inhibits eukaryotic protein synthesis by sequestering Hsp70 which is required for maintaini...

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Bibliografiska uppgifter
Huvudupphovsmän: Ramya, T. N. C., Surolia, Namita, Surolia, Avadhesha
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2006
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820809/
https://ncbi.nlm.nih.gov/pubmed/16952278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060879
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