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15-Deoxyspergualin inhibits eukaryotic protein synthesis through eIF2α phosphorylation
DSG (15-deoxyspergualin), an immunosuppressant with tumoricidal properties, binds potently to the regulatory C-terminal ‘EEVD’ motif of Hsps (heat-shock proteins). In the present study we demonstrate that DSG inhibits eukaryotic protein synthesis by sequestering Hsp70 which is required for maintaini...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820809/ https://ncbi.nlm.nih.gov/pubmed/16952278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060879 |
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