Endogenous IL-12 triggers an antiangiogenic program in melanoma cells

The IL12RB2 gene acts as a tumor suppressor in human B cell malignancies. Indeed, Il12rb2 knockout (KO) mice develop spontaneously B cell tumors, but also lung epithelial tumors. This latter phenotype may be related to (i) impairment of host IL-12-mediated immunosurveillance and/or (ii) IL-12 inabil...

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Main Authors: Airoldi, Irma, Di Carlo, Emma, Cocco, Claudia, Taverniti, Giuseppe, D'Antuono, Tommaso, Ognio, Emanuela, Watanabe, Morihiro, Ribatti, Domenico, Pistoia, Vito
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820697/
https://ncbi.nlm.nih.gov/pubmed/17360466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609028104
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