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Effect of ketoconazole on isolated mitochondria from Candida albicans.

Ketoconazole, an oral antimycotic imidazole drug, blocked the transport of electrons in the respiratory chain of Candida albicans under aerobic conditions with different substrates, such as NADH and succinate. This effect was a nonspecific inhibition of NADH oxidases and succinate oxidases. The addi...

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Bibliographic Details
Main Authors: Shigematsu, M L, Uno, J, Arai, T
Format: Artigo
Language:Inglês
Published: 1982
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC182046/
https://ncbi.nlm.nih.gov/pubmed/6287930
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