Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Mice with a disrupted mdr2 gene completely lack biliary phospholipid excretion and develop progressive liver...

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Detalhes bibliográficos
Main Authors: de Vree, J. Marleen L., Jacquemin, Emmanuel, Sturm, Ekkehard, Cresteil, Danièle, Bosma, Piter J., Aten, Jan, Deleuze, Jean-François, Desrochers, Marc, Burdelski, Martin, Bernard, Olivier, Elferink, Ronald P. J. Oude, Hadchouel, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18201/
https://ncbi.nlm.nih.gov/pubmed/9419367
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