Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1

BACKGROUND: Antigenic chimeric viruses have previously been generated in which the structural genes of recombinant dengue virus type 4 (rDEN4) have been replaced with those derived from DEN2 or DEN3. Two vaccine candidates were identified, rDEN2/4Δ30(ME) and rDEN3/4Δ30(ME), which contain the membran...

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Hlavní autoři: Blaney, Joseph E, Sathe, Neeraj S, Hanson, Christopher T, Firestone, Cai Yen, Murphy, Brian R, Whitehead, Stephen S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819370/
https://ncbi.nlm.nih.gov/pubmed/17328799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-23
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