Influence of Urinary pH on the Pharmacokinetics of Cinoxacin in Humans and on Antibacterial Activity In Vitro

The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbona...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Barbhaiya, Rashmi H., Gerber, Andreas U., Craig, William A., Welling, Peter G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1982
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7103450/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.21.3.472
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