Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

We have used a recently described animal model to characterize the ocular pharmacokinetics of sparfloxacin in vitreous humor of uninfected albino rabbits following systemic administration and direct intraocular injection. The relationships of lipophilicity, protein binding, and molecular weight to t...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Liu, Weiguo, Liu, Qing Feng, Perkins, Ruth, Drusano, George, Louie, Arnold, Madu, Assumpta, Mian, Umar, Mayers, Martin, Miller, Michael H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1417
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