Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

We have used a recently described animal model to characterize the ocular pharmacokinetics of sparfloxacin in vitreous humor of uninfected albino rabbits following systemic administration and direct intraocular injection. The relationships of lipophilicity, protein binding, and molecular weight to t...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Liu, Weiguo, Liu, Qing Feng, Perkins, Ruth, Drusano, George, Louie, Arnold, Madu, Assumpta, Mian, Umar, Mayers, Martin, Miller, Michael H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1417
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!